An elevation in alkaline phosphatase with a high GGT indicates what kind of abnormality?

An elevation in alkaline phosphatase (ALP) alongside a high level of gamma-glutamyl transferase (GGT) is indicative of a liver abnormality. ALP is an enzyme found in various tissues, primarily in the liver and bones, and is particularly associated with the biliary system. GGT, on the other hand, is an enzyme that is closely linked to the liver and is often used as a more specific marker for liver dysfunction than ALP alone.

When both ALP and GGT are elevated, it suggests that the source of the elevated ALP is likely hepatic rather than from a bone disorder. In bone disease, ALP may be elevated, but GGT usually remains normal. Therefore, the combination of high ALP and high GGT directs attention towards liver-related conditions, such as cholestasis or liver cell injury. These could include conditions like biliary obstruction, liver disease, or hepatitis, making the presence of both elevated enzymes a significant indicator of hepatic dysfunction rather than other potential issues, such as muscle injury or kidney dysfunction.