What term describes the condition associated with elevated AST and ALT levels?

Transaminitis is the term used to describe the condition characterized by elevated levels of the liver enzymes aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the blood. These enzymes are typically present in liver cells, and their elevation indicates hepatocellular injury or inflammation.

While hepatitis is one specific condition that can lead to transaminitis, the term "transaminitis" itself is more general and applies to any situation where there is an increase in AST and ALT. This could include various other conditions such as alcoholic liver disease, non-alcoholic fatty liver disease, and even heart failure or muscle injury, which may also cause elevations in these liver enzymes.

Cirrhosis and cholestasis are also related to liver conditions; however, cirrhosis typically presents with significantly altered liver function and may not always show markedly elevated AST and ALT levels, particularly in advanced stages. Cholestasis refers to a different mechanism of liver damage often related to bile flow obstruction and typically elevates different enzymes (alkaline phosphatase) rather than predominantly AST and ALT.

Understanding transaminitis is crucial because it guides healthcare providers in diagnosing the underlying causes of liver disease and monitoring liver health.